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Dissemination in Space
DIS can be demonstrated by ≥ 1 T2 lesion * in at least two out of four areas of the CNS:

- periventricular
- juxtacortical
- infratentorial

- spinal cord**


Await a further clinical attack implicating a different CNS site.
* Gadolinium enhancement of lesions is not required for DIS.
** If a subject has a brainstem or spinal cord syndrome, the symptomatic lesions are excluded from the Criteria and do not contribute to lesion count.